Mannose-Binding Lectin 2 (MBL2) combined genotypes deficiency is associated with susceptibility for Oral Lichen Planus
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چکیده
منابع مشابه
P 144: Sunflower Mannose binding Lectin-Associated Serine Protease Inhibitor-1 (SFMI-1) and -2: Significant Inhibitors of Mannose binding Lectin Pathway which Helps in Multiple Sclerosis Treatment
One of the important parts of innate immunity is complement system that occurs in three different ways; the classic, the alternative and the lectin pathway. The four pattern recognition molecules that have been identified till now are Mannose binding lectin (MBL), a component of lectin pathway, and three ficolins (ficolin1,-2 and -3) which compound to the carbohydrates of the cell surface. MBL ...
متن کاملCombined genotypes of the MBL2 gene related to low mannose-binding lectin levels are associated with vaso-occlusive events in children with sickle cell anemia
Sickle cell anemia (SCA) presents heterogenous clinical manifestations that cannot be explained solely by alterations to hemoglobin (Hb); other components such as endothelial adhesion, thrombosis and inflammation may be involved. The mannose-binding lectin (MBL) has an important role in innate immunity and inflammatory diseases. In this report, we describe an association between MBL2 polymorphi...
متن کاملMannose-binding lectin-2 genotypes and recurrent late pregnancy losses.
BACKGROUND Low levels of mannose-binding lectin (MBL) predispose to various infectious and inflammatory disorders and have been reported to be associated with recurrent early miscarriages. Recurrent late pregnancy losses (RLPL) in the second trimester is a rare but devastating syndrome where maternal rather than fetal causes are likely to play a stronger role than in early recurrent miscarriage...
متن کاملOral-esophageal lichen planus associated with oral squamous cell carcinoma.
Although ultraviolet radiation may be an important etiologic factor for BCCs on sun-exposed areas, the cause of their occurrence on areas not exposed to sun has not been identified. Chronic skin irritation, previous trauma, exposure to ionizing radiation, coal tar and other carcinogens or immunosuppressive drugs may be responsible for the development of tumors at uncommon sites.[1,2] In our cas...
متن کاملMannose-Binding Lectin Deficiency Is Associated with Myocardial Infarction: The HUNT2 Study in Norway
OBJECTIVES Mannose-binding lectin (MBL) and ficolins activate the complement cascade, which is involved in atherogenesis. Based on a pilot study, we hypothesized that functional polymorphisms in the MBL gene (MBL2) leading to dysfunctional protein are related to development of myocardial infarction (MI). The aim of the present study was to study polymorphisms in MBL2 and ficolin genes in relati...
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ژورنال
عنوان ژورنال: Genetics and Molecular Biology
سال: 2019
ISSN: 1678-4685,1415-4757
DOI: 10.1590/1678-4685-gmb-2018-0015